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Image Search Results
Journal: Scientific Reports
Article Title: Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
doi: 10.1038/s41598-021-91528-1
Figure Lengend Snippet: Effects of ATX-II on human ventricular contractility. ( a – e ) show typical contractility transients recorded from a ventricular cell at a pacing of 1 Hz in the presence of vehicle control and after exposure to four ascending concentrations of ATX-II. ( f ) shows ATX-effect curve for sarcomere shortening as a function of concentrations tested (EC 50 = 0.012 µM, n = 6 cells). ( g ) shows mean % incidence of aftercontraction and contraction failure when cardiomyocytes were incubated with ATX-II at 1 Hz pacing frequency. *,* p < 0.05 versus values from vehicle control. IonWizard software (v1.2.22, IonOptix LLC, MA, USA, www.ionoptix.com ) and SigmaPlot v14.0 (Systat Software Inc., CA, USA, www.systatsoftware.com ) were used to generate the representative contractility transients and fitted C-E curve, respectively.
Article Snippet:
Techniques: Control, Incubation, Software
Journal: Scientific Reports
Article Title: Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
doi: 10.1038/s41598-021-91528-1
Figure Lengend Snippet: Effects of GS-967 on human ventricular contractility in condition mimicking LQTS2. ( a – c ) show typical contractility transients recorded from a ventricular cell at a pacing of 1 Hz in the presence of vehicle control ( a ) and after exposure to 1 µM E-4031 alone ( b ) or in combination with 0.3 µM GS-967 ( c ). ( d ) and ( e ) show mean % change in sarcomere shortening ( d ) and mean % incidence of aftercontraction and contraction failure ( e ) when cardiomyocytes were treated with 1 µM E-4031 alone or in combination with 0.3 µM GS-967 (n = 8 cells) at 1 Hz. * p < 0.05 versus values from vehicle control. # p < 0.05 versus values from E-4031. IonWizard software (v1.2.22, IonOptix LLC, MA, USA, www.ionoptix.com ) was used to generate the representative contractility transients.
Article Snippet:
Techniques: Control, Software
Journal: Scientific Reports
Article Title: Arrhythmogenic and antiarrhythmic actions of late sustained sodium current in the adult human heart
doi: 10.1038/s41598-021-91528-1
Figure Lengend Snippet: Effects of GS-967 on human atrial contractility in condition mimicking LQTS3. ( a – c ) show typical contractility transients recorded from a ventricular cell at a pacing of 1 Hz in the presence of vehicle control ( a ) and after exposure to 0.03 µM ATX-II alone ( b ) or in combination with 0.3 µM GS-967 ( c ). ( d ) and ( e ) show mean % change in sarcomere shortening ( d ) and mean % incidence of aftercontraction and contraction failure ( e ) when cardiomyocytes were treated with 0.03 µM ATX-II alone or in combination with 0.3 µM GS-967 (n = 5 cells) at 1 Hz. *,* p < 0.05 versus values from vehicle control. #,# p < 0.05 versus values from ATX-II. IonWizard software (v1.2.22, IonOptix LLC, MA, USA, www.ionoptix.com ) was used to generate the representative contractility transients.
Article Snippet:
Techniques: Control, Software